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KMID : 0363420070210010173
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Journal of Korean Oriental Pediatrics
2007 Volume.21 No. 1 p.173 ~ p.187
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Effects of Kammaegdaejotang on the hemodynamic function in the isolated perfused rat heart
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Kim Deog-Gon
Park Sung-Nam
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Abstract
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Objectives: In order to verify the cardiovascular hemodynamic function of Kammaegdaejo-tang, the experiment was performed in the rats.
Methods: Twelve hearts removed from male Sparague-Dawley rats weighing between 250g and 300g were perfused by the Langendorff technique with modified 37 Krebs-Henseleit’s buffer solution at a constant perfusion pressure. They were randomly assigned to one of two groups, supplied with either normal saline or Kammaegdaejotang administration. Heart rate, left ventricular pressure, +dp/dt maximum, -dp/dt maximum, and -dp/dt/ +dp/dt ratio were evaluated at baseline after the administration of either normal saline or Kammaegdaejotang.
Results: Kammaegdaejotang made the heart rate increasing significantly (p<0.05). Kammaegdaejotang did not effectively work on left ventricular pressure of the isolated heart(p=0.11, no significance). The significant effects of Kammaegdaejotang were observed on +dp/dt max and -dp/dt max(p<0.05). Kammaegdaejotang did not effectively work on -dp/dt/ +dp/dt ratio(p=0.24, no significance).
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KEYWORD
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Kammaegdaejotang, Hemodynamic Function, Isolated Perfused Rat Heart
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